How do you fix an upside down laptop screen?

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My laptop screen started going upside down and mouse traveled up. When the issue was occasional, I used the quick keystroke Ctrl-Alt-up arrow" combination to resolve the issue.

Permanent Fix:

Of late, the issue happened to me very often. Sometimes it goes upside down on every click on desktop.

 To solve this permanently, I enabled "Rotation Lock" in Display Settings (Windows 8.x to 10)

Display settings Rotation Lock 

Tip:

If the screen upside down is caused by accidentally hitting keys on the keyboard, use this simple process: If you hold down the CTRL and the ALT key and hit the up arrow that will straighten your screen out.

Happy troubleshooting.